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  • 김원구 부교수

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    • 02-3010-5883
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    갑상선질환

    소속연구단

    관련/관심분야

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    주요논문

    1. Long-Term Changes in the Mortality Rates of Thyroid Cancer in Korea: Analysis of Korean National Data from 1985 to 2020 [ Endocrinology and Metabolism ] - 2023.10.01
    2. Inflammatory biomarkers predict outcomes of patients with radioactive iodine refractory thyroid cancer treated with sorafenib [ ENDOCRINE ] - 2023.08.01
    3. Serum thyroglobulin testing after thyroid lobectomy in patients with 1-4 cm papillary thyroid carcinoma [ ENDOCRINE ] - 2023.08.01
    4. Long-term follow-up result of antithyroid drug treatment of Graves' hyperthyroidism in a large cohort [ European Thyroid Journal ] - 2023.03.17
    5. Lenvatinib Compared with Sorafenib as a First-Line Treatment for Radioactive Iodine-Refractory, Progressive, Differentiated Thyroid Carcinoma: Real-World Outcomes in a Multicenter Retrospective Cohort Study [ THYROID ] - 2023.01.27
    6. Prognosis of Patients with 1-4 cm Papillary Thyroid Cancer Who Underwent Lobectomy: Focus on Gross Extrathyroidal Extension Invading Only the Strap Muscles [ ANNALS OF SURGICAL ONCOLOGY ] - 2022.11.01
    7. Recent Changes in the Incidence of Thyroid Cancer in Korea between 2005 and 2018: Analysis of Korean National Data [ Endocrinology and Metabolism ] - 2022.10.01
    8. Effects of dabrafenib and erlotinib combination treatment on anaplastic thyroid carcinoma [ ENDOCRINE-RELATED CANCER ] - 2022.05.09
    9. Immunoglobulin G4-Related Thyroid Disease: A Single-Center Experience and Literature Review [ ENDOCRINOLOGY AND METABOLISM ] - 2022.04.27
    10. Effect of TSH levels during active surveillance of PTMC according to age [ ENDOCRINE-RELATED CANCER ] - 2022.03.01
    11. Clinical implications of age and excellent response to therapy in patients with high-risk differentiated thyroid carcinoma [ CLINICAL ENDOCRINOLOGY ] - 2021.12.01
    12. Mutation in Genes Encoding Key Functional Groups Additively Increase Mortality in Patients with BRAF(V600E)-Mutant Advanced Papillary Thyroid Carcinoma [ CANCERS ] - 2021.11.22
    13. Death-Associated Protein Kinase 1 Inhibits Progression of Thyroid Cancer by Regulating Stem Cell Markers [ CELLS ] - 2021.11.03
    14. Clinicopathological Characteristics and Disease-Free Survival in Patients with Hurthle Cell Carcinoma: A Multicenter Cohort Study in South Korea [ ENDOCRINOLOGY AND METABOLISM ] - 2021.10.28
    15. Gender-Dependent Reference Range of Serum Calcitonin Levels in Healthy Korean Adults [ ENDOCRINOLOGY AND METABOLISM ] - 2021.04.26
    16. Genetic profiles of aggressive variants of Papillary thyroid carcinomas [ Cancers ] - 2021.02.20
    17. Mitofusin-2 modulates the epithelial to mesenchymal transition in thyroid cancer progression [ SCIENTIFIC REPORTS ] - 2021.01.21
    18. Immune Profiling of Advanced Thyroid Cancers Using Fluorescent Multiplex Immunohistochemistry [ THYROID ] - 2021.01.15
    19. Clinical Outcomes after Early and Delayed Radioiodine Remnant Ablation in Patients with Low-Risk Papillary Thyroid Carcinoma: Propensity Score Matching Analysis [ Endocrinology and Metabolism ] - 2020.12.24
    20. High Phosphoglycerate Dehydrogenase Expression Induces Stemness and Aggressiveness in Thyroid Cancer [ THYROID ] - 2020.11.12
    21. Clinical Implication of World Health Organization Classification in Patients with Follicular Thyroid Carcinoma in South Korea: A Multicenter Cohort Study [ Endocrinology and Metabolism ] - 2020.09.22
    22. Genetic profile of advanced thyroid cancers in relation to distant metastasis. [ ENDOCRINE-RELATED CANCER ] - 2020.05.01
    23. Modified risk stratification based on cervical lymph node metastases following lobectomy for papillary thyroid carcinoma. [ CLINICAL ENDOCRINOLOGY ] - 2020.04.01
    24. Quality of Life in Patients with Papillary Thyroid Microcarcinoma According to Treatment: Total Thyroidectomy with or without Radioactive Iodine Ablation [ ENDOCRINOLOGY AND METABOLISM ] - 2020.03.27
    25. Association between urinary sodium levels and iodine status in Korea [ KOREAN JOURNAL OF INTERNAL MEDICINE ] - 2020.03.16
    26. Estimating the Growth Rate of Lung Metastases in Differentiated Thyroid Carcinoma: Response Evaluation Criteria in Solid Tumors or Doubling Time? [ THYROID ] - 2020.03.16
    27. Extended Real-World Observation of Patients Treated with Sorafenib for Radioactive Iodine-Refractory Differentiated Thyroid Carcinoma and Impact of Lenvatinib Salvage Treatment: A Korean Multicenter Study [ THYROID ] - 2019.12.20
    28. Clinical Significance of Gross Invasion of Strap Muscles in Patients With 1- to 4-cm-Sized Papillary Thyroid Carcinoma Undergoing Lobectomy. [ ANNALS OF SURGICAL ONCOLOGY ] - 2019.12.01
    29. Determining whether tumor volume doubling time and growth rate can predict malignancy after delayed diagnostic surgery of follicular neoplasms. [ THYROID ] - 2019.10.20
    30. Expression of NF2 Modulates the Progression of BRAFV600E Mutated Thyroid Cancer Cells. [ Endocrinology and Metabolism ] - 2019.06.25
    31. Tumor Volume Doubling Time in Active Surveillance of Papillary Thyroid Carcinoma [ THYROID ] - 2019.05.20
    32. Mutational profile of papillary thyroid microcarcinoma with extensive lymph node metastasis [ ENDOCRINE ] - 2019.04.01
    33. The role of Slit2 as a tumor suppressor in thyroid cancer [ MOLECULAR AND CELLULAR ENDOCRINOLOGY ] - 2019.03.01
    34. A Relook at the T Stage of Differentiated Thyroid Carcinoma with a Focus on Gross Extrathyroidal Extension. [ THYROID ] - 2019.02.14
    35. Tumor Growth Rate Does Not Predict Malignancy in Surgically Resected Thyroid Nodules Classified as Bethesda Category III with Architectural Atypia. [ THYROID ] - 2019.02.14
    36. Lobectomy Is Feasible for 1-4?cm Papillary Thyroid Carcinomas: A 10-Year Propensity Score Matched-Pair Analysis on Recurrence. [ THYROID ] - 2019.01.21
    37. Eighth edition of tumor-node-metastasis staging system improve survival predictability for papillary, but not follicular thyroid carcinoma: A multicenter cohort study [ ORAL ONCOLOGY ] - 2018.12.01
    38. 렌바티닙 사용과 관련된 고혈압과 단백뇨의 관리: 증례 보고 [ International Journal of Thyroidology ] - 2018.11.01
    39. Modification of the eight-edition tumor-node-metastasis staging system with N1b for papillary thyroid carcinoma: A multi-institutional cohort study [ ORAL ONCOLOGY ] - 2018.11.01
    40. Decreasing Disease-Specific Mortality of Differentiated Thyroid Cancer in Korea: A Multicenter Cohort Study [ THYROID ] - 2018.09.10
    41. Do aggressive variants of papillary thyroid carcinoma have worse clinical outcome than classic papillary thyroid carcinoma? [ EUROPEAN JOURNAL OF ENDOCRINOLOGY ] - 2018.09.01
    42. Changes in Serum Thyroglobulin Levels After Lobectomy in Patients with Low-Risk Papillary Thyroid Cancer. [ THYROID ] - 2018.08.13
    43. Tumour growth rate of follicular thyroid carcinoma is not different from that of follicular adenoma. [ CLINICAL ENDOCRINOLOGY ] - 2018.06.01
    44. Prognostic Implication of N1b Classification in the Eighth Edition of the Tumor-Node-Metastasis Staging System of Differentiated Thyroid Cancer. [ THYROID ] - 2018.04.13
    45. BRAF and RAS Mutational Status in Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and Invasive Subtype of Encapsulated Follicular Variant of Papillary Thyroid Carcinoma in Korea. [ THYROID ] - 2018.04.13
    46. Mechanisms Linking Obesity and Thyroid Cancer Development and Progression in Mouse Models. [ Hormones & Cancer ] - 2018.04.02
    47. Comparison of Immunohistochemistry and Direct Sanger Sequencing for Detection of the BRAF(V600E) Mutation in Thyroid Neoplasm. [ Endocrinology and Metabolism ] - 2018.03.30
    48. Tertiary Care Experience of Sorafenib in the Treatment of Progressive Radioiodine-Refractory Differentiated Thyroid Carcinoma: A Korean Multicenter Study [ THYROID ] - 2018.03.19
    49. Preoperative Clinical and Sonographic Predictors for Lateral Cervical Lymph Node Metastases in Sporadic Medullary Thyroid Carcinoma. [ THYROID ] - 2018.03.19
    50. Practical Initial Risk Stratification Based on Lymph Node Metastases in Pediatric and Adolescent Differentiated Thyroid Cancer. [ THYROID ] - 2018.02.18
    51. A Follow-Up Strategy for Patients with an Excellent Response to Initial Therapy for Differentiated Thyroid Carcinoma: Less Is Better. [ THYROID ] - 2018.02.12
    52. Development of thyroid dysfunction is associated with clinical response to PD-1 blockade treatment in patients with advanced non-small cell lung cancer [ OncoImmunology ] - 2018.01.02
    53. Preoperative clinicopathological characteristics of patients with solitary encapsulated follicular variants of papillary thyroid carcinomas. [ JOURNAL OF SURGICAL ONCOLOGY ] - 2017.11.01
    54. Age-specific reference interval of serum TSH levels is high in adolescence in an iodine excess area: Korea national health and nutrition examination survey data [ ENDOCRINE ] - 2017.09.01
    55. Growth Kinetics of Macronodular Lung Metastases and Survival in Differentiated Thyroid Carcinoma. [ THYROID ] - 2017.07.05
    56. Clinical outcomes after delayed thyroid surgery in patients with papillary thyroid microcarcinoma [ EUROPEAN JOURNAL OF ENDOCRINOLOGY ] - 2017.07.01
    57. Features of papillary thyroid microcarcinoma associated with lateral cervical lymph node metastasis. [ CLINICAL ENDOCRINOLOGY ] - 2017.06.01
    58. Clinical Features of Early and Late Postoperative Hypothyroidism after Lobectomy. [ JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM ] - 2017.04.10
    59. Dynamic Risk Stratification for Predicting Recurrence in Patients with Differentiated Thyroid Cancer Treated Without Radioactive Iodine Remnant Ablation Therapy. [ THYROID ] - 2017.04.03
    60. Thyroid Stimulating Hormone Reference Range and Prevalence of Thyroid Dysfunction in the Korean Population: Korea National Health and Nutrition Examination Survey 2013 to 2015. [ Endocrinology and Metabolism ] - 2017.03.24
    61. Serum vitamin D3 levels are not associated with thyroid cancer prevalence in euthyroid subjects without autoimmune thyroid disease. [ Korean Journal of Internal Medicine ] - 2017.01.01
    62. Development of Tracheoesophageal Fistula after the Use of Sorafenib in Locally Advanced Papillary Thyroid Carcinoma: a Case Report [ International Journal of Thyroidology ] - 2016.11.01
    63. Early prognostic factors at the time of diagnosis of bone metastasis in patients with bone metastases of differentiated thyroid carcinoma. [ EUROPEAN JOURNAL OF ENDOCRINOLOGY ] - 2016.09.01
    64. Dynamic risk stratification for medullary thyroid cancer according to the response to initial therapy [ ENDOCRINE ] - 2016.07.01
    65. Usefulness of Measuring Thyroid Stimulating Antibody at the Time of Antithyroid Drug Withdrawal for Predicting Relapse of Graves Disease. [ Endocrinology and Metabolism ] - 2016.06.28
    66. Clinicopathological Features Associated With the Prognosis of Patients With Adrenal Cortical Carcinoma: Usefulness of the Ki-67 Index. [ MEDICINE ] - 2016.05.30
    67. Genomic Alterations of Anaplastic Thyroid Carcinoma Detected by Targeted Massive Parallel Sequencing in a BRAF(V600E) Mutation-Prevalent Area. [ THYROID ] - 2016.05.01
    68. Low Prevalence of Somatic TERT Promoter Mutations in Classic Papillary Thyroid Carcinoma [ Endocrinology and Metabolism ] - 2016.03.01
    69. Changing Trends in the Clinicopathological Features and Clinical Outcomes of Medullary Thyroid Carcinoma [ JOURNAL OF SURGICAL ONCOLOGY ] - 2016.02.01
    70. Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells [ MOLECULAR AND CELLULAR ENDOCRINOLOGY ] - 2016.01.05
    71. Sub-Classification of Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma by Pathologic Criteria [ PLoS One ] - 2015.07.17
    72. Changes in the Pulmonary Function Test after Radioactive Iodine Treatment in Patients with Pulmonary Metastases of Differentiated Thyroid Cancer [ PLoS One ] - 2015.04.29
    73. Thyroglobulin Level in Fine-Needle Aspirates for Preoperative Diagnosis of Cervical Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma: Two Different Cutoff Values According to Serum Thyroglobulin Level [ THYROID ] - 2015.04.01
    74. A cut-off value of basal serum calcitonin for detecting macroscopic medullary thyroid carcinoma [ CLINICAL ENDOCRINOLOGY ] - 2015.04.01
    75. The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells. [ The Korean Journal of Internal Medicine ] - 2014.07.01
    76. Follicular and Hurthle cell carcinoma of the thyroid in iodine-sufficient area: retrospective analysis of Korean multicenter data [ Korean Journal of Internal Medicine ] - 2014.05.01
    77. Association Between Expression of X-Linked Inhibitor of Apoptosis Protein and the Clinical Outcome in a BRAF(V600E)-Prevalent Papillary Thyroid Cancer Population [ THYROID ] - 2014.04.01
    78. Low levels of serum vitamin d3 are associated with autoimmune thyroid disease in pre-menopausal women [ THYROID ] - 2014.04.01
    79. Inhibition of Tumorigenesis by the Thyroid Hormone Receptor β in Xenograft Models. [ THYROID ] - 2014.02.03

    연구과제 수주실적

    1. 단백질체 분석을 통한 미결정형 갑상선 결절의 분자진단법 개발 - 2024.03.01 ~ 2025.02.28
    2. 단백질체 분석을 통한 미결정형 갑상선 결절의 분자진단법 개발 - 2023.03.01 ~ 2024.02.29
    3. 단백질체 분석을 통한 미결정형 갑상선 결절의 분자진단법 개발 - 2022.03.01 ~ 2023.02.28
    4. 렌비마 사용성적조사 - 2021.06.09 ~ 2021.10.06
    5. 중심부 생검 검체의 단백질체 분석을 통한 미결정형 갑상선결절의 진단적 바이오마커 발굴 - 2021.01.01 ~ 2021.12.31
    6. 단백질체 분석을 통한 갑상선 여포암 특이적 진단 바이오마커 발굴(3) - 2020.11.01 ~ 2021.10.31
    7. 단백질체 분석을 통한 갑상선 여포암 특이적 진단 바이오마커 발굴(2) - 2019.11.01 ~ 2020.10.31
    8. 단백질체 분석을 통한 갑상선 여포암 특이적 진단 바이오마커 발굴 - 2018.11.01 ~ 2019.10.31
    9. 유두암종 세포핵을 지닌 비침습 갑상선 소포종양을 감별 진단할 수 있는 바이오마커 발굴 - 2018.01.01 ~ 2018.12.31
    10. 갑상선암에서 NF2의 역할 - 2018.01.01 ~ 2018.12.31
    11. 난치성/전이성 갑상선암 치료의 새로운 표적 발굴 (3) - 2017.07.01 ~ 2018.06.30
    12. 단백질체 분석을 통한 갑상선 여포암 진단을 위한 바이오마커 발굴 - 2017.01.01 ~ 2017.12.31
    13. 난치성/전이성 갑상선암 치료의 새로운 표적 발굴 (2) - 2016.07.01 ~ 2017.06.30
    14. 갑상선암 대사체 분석을 통한 치료 표적 발굴 - 2016.01.01 ~ 2016.12.31
    15. 난치성/전이성 갑상선암 치료의 새로운 표적 발굴 (1) - 2015.07.01 ~ 2016.06.30
    16. 차세대 염기서열 분석기법을 활용한 악성 갈색세포종 및 부신피질암 환자의 유전자 변이 연구 - 2015.04.17 ~ 2016.12.31
    17. Slit-Robo 신호전달에서 갑상선암의 바이오마커 및 표적 발굴 - 2015.01.01 ~ 2015.12.31
    18. 갑상선암에서 Roundabout 경로의 역할 - 2014.11.01 ~ 2017.12.31
    19. 차세대 염기서열 분석기법을 활용한 전이성 분화갑상선암 환자의 유전자 변이 연구 - 2014.08.22 ~ 2015.08.30
    20. 차세대 염기서열 분석기법을 활용한 역형성 갑상선암 환자의 유전자 변이 연구 - 2014.06.19 ~ 2015.05.23
    21. 갑상선암에서 Rac1의 역할 - 2014.01.01 ~ 2014.12.31
    22. 갑상선암에서 Rac1의 역할 - 2013.07.01 ~ 2013.12.31

    특허/기술이전실적

    1. 피막형 여포변이 갑상선 유두암과 유두암종유사핵모양비침습소포종양 분류용 조성물 및 이를 이용한 분류 방법 - 2022.07.19
    2. 갑상선 여포 종양의 감별진단용 조성물 및 이를 이용한 감별진단 방법 - 2022.05.12

    국내외 경력

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