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  • 김경원 교수

    영상의학

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    복부영상의학

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    주요논문

    1. Deep learning?based prediction of post?pancreaticoduodenectomy pancreatic fistula [ SCIENTIFIC REPORTS ] - 2024.03.01
    2. Whole Process of Standardization of Diffusion-Weighted Imaging: Phantom Validation and Clinical Application According to the QIBA Profile [ Diagnostics ] - 2024.03.01
    3. Mapping Changes in Glutamate with Glutamate-Weighted MRI in Forced Swim Test Model of Depression in Rats [ Biomedicines ] - 2024.02.07
    4. Sequence-Type Classification of Brain MRI for Acute Stroke Using a Self-Supervised Machine Learning Algorithm. [ Diagnostics ] - 2023.12.01
    5. CCR8 as a Therapeutic Novel Target: Omics-Integrated Comprehensive Analysis for Systematically Prioritizing Indications [ Biomedicines ] - 2023.10.27
    6. Comprehensive Analysis for Anti-Cancer Target-Indication [ Biology ] - 2023.07.07
    7. Artificial Intelligence in Gastric Cancer Imaging With Emphasis on Diagnostic Imaging and Body Morphometry [ JOURNAL OF GASTRIC CANCER ] - 2023.07.01
    8. Prognostic artificial intelligence model to predict 5 year survival at 1 year after gastric cancer surgery based on nutrition and body morphometry [ JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE ] - 2023.04.03
    9. Development and validation of a deep learning model to diagnose COVID-19 using time-series heart rate values before the onset of symptoms [ JOURNAL OF MEDICAL VIROLOGY ] - 2023.02.01
    10. Evolution of Radiological Treatment Response Assessments for Cancer Immunotherapy: From iRECIST to Radiomics and Artificial Intelligence [ KOREAN JOURNAL OF RADIOLOGY ] - 2022.11.01
    11. Prognostic Value of Sarcopenia and Myosteatosis in Patients with Resectable Pancreatic Ductal Adenocarcinoma [ KOREAN JOURNAL OF RADIOLOGY ] - 2022.11.01
    12. Artificial intelligence for predicting five-year survival in stage IV metastatic breast cancer patients: A focus on sarcopenia and other host factors [ Frontiers in Physiology ] - 2022.09.01
    13. Impact of Baseline Muscle Mass and Myosteatosis on the Development of Early Toxicity During First-Line Chemotherapy in Patients With Initially Metastatic Pancreatic Cancer [ Frontiers in Oncology ] - 2022.05.20
    14. Development and validation of an ensemble artificial intelligence model for comprehensive imaging quality check to classify body parts and contrast enhancement [ BMC MEDICAL IMAGING ] - 2022.05.13
    15. Safety and Efficacy of Chimeric Antigen Receptor T-Cell Therapy for Glioblastoma: A Systemic Review and Meta-Analysis [ Frontiers in Oncology ] - 2022.05.01
    16. Change of Computed Tomography-Based Body Composition after Adrenalectomy in Patients with Pheochromocytoma [ CANCERS ] - 2022.04.13
    17. Artificial Intelligence Mortality Prediction Model for Gastric Cancer Surgery Based on Body Morphometry, Nutritional, and Surgical Information: Feasibility Study [ APPLIED SCIENCES-BASEL ] - 2022.04.12
    18. A reliable and robust method for the upper thigh muscle quantification on computed tomography: toward a quantitative biomarker for sarcopenia [ BMC MUSCULOSKELETAL DISORDERS ] - 2022.01.27
    19. Subcutaneous fat area at the upper thigh level is a useful prognostic marker in the elderly with femur fracture [ JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE ] - 2021.12.01
    20. Effects of Contrast Phases on Automated Measurements of Muscle Quantity and Quality Using CT [ KOREAN JOURNAL OF RADIOLOGY ] - 2021.11.01
    21. Development of a fully automatic deep learning system for L3 selection and body composition assessment on computed tomography [ SCIENTIFIC REPORTS ] - 2021.11.01
    22. Feasibility of a Drug-Releasing Radiofrequency Ablation System in a Porcine Liver Model [ APPLIED SCIENCES-BASEL ] - 2021.09.01
    23. Comprehensive Updates in the Role of Imaging for Multiple Myeloma Management Based on Recent International Guidelines [ KOREAN JOURNAL OF RADIOLOGY ] - 2021.09.01
    24. Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia [ AGEING RESEARCH REVIEWS ] - 2021.09.01
    25. Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes [ JOURNAL OF CLINICAL MEDICINE ] - 2021.08.01
    26. Long-Term Outcomes After In-Hospital Cardiac Arrest: Does Pre-arrest Skeletal Muscle Depletion Matter? [ FRONTIERS IN PHYSIOLOGY ] - 2021.07.29
    27. Age-related changes in muscle quality and development of diagnostic cutoff points for myosteatosis in lumbar skeletal muscles measured by CT scan [ CLINICAL NUTRITION ] - 2021.06.01
    28. Incidence of Immune-Mediated Pseudoprogression of Lymphoma Treated with Immune Checkpoint Inhibitors: Systematic Review and Meta-Analysis [ JOURNAL OF CLINICAL MEDICINE ] - 2021.05.01
    29. CDISC-compliant clinical trial imaging management system with automatic verification and data Transformation: Focusing on tumor response assessment data in clinical trials [ JOURNAL OF BIOMEDICAL INFORMATICS ] - 2021.05.01
    30. Reliability of Skeletal Muscle Area Measurement on CT with Different Parameters: A Phantom Study [ KOREAN JOURNAL OF RADIOLOGY ] - 2021.04.01
    31. Definition, Incidence, and Challenges for Assessment of Hyperprogressive Disease During Cancer Treatment With Immune Checkpoint Inhibitors A Systematic Review and Meta-analysis [ JAMA NETWORK OPEN ] - 2021.03.01
    32. Impact of liver-stiffness measurement on hepatocellular carcinoma development in chronic hepatitis C patients treated with direct-acting antivirals: A systematic review and time-to-event meta-analysis [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2021.03.01
    33. Preoperative nutritional risk index and postoperative one-year skeletal muscle loss can predict the prognosis of patients with gastric adenocarcinoma: a registry-based study [ BMC CANCER ] - 2021.02.12
    34. Comparison of RECIST 1.1 and irecist in patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis [ Cancers ] - 2021.01.01
    35. Reference Data and T-Scores of Lumbar Skeletal Muscle Area and Its Skeletal Muscle Indices Measured by CT Scan in a Healthy Korean Population [ JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES ] - 2021.01.01
    36. Tract ablation after radiofrequency ablation to prevent viable tumor cell adhesion to the needle electrode [ INTERNATIONAL JOURNAL OF HYPERTHERMIA ] - 2020.11.01
    37. Incidence of Pseudoprogression during Immune Checkpoint Inhibitor Therapy for Solid Tumors: A Systematic Review and Meta-Analysis [ RADIOLOGY ] - 2020.10.01
    38. Assessment of Myosteatosis on Computed Tomography by Automatic Generation of a Muscle Quality Map Using a Web-Based Toolkit: Feasibility Study [ JMIR Medical Informatics ] - 2020.10.01
    39. Impact of pseudoprogression and treatment beyond progression on outcome in patients with non-small cell lung cancer treated with immune checkpoint inhibitors [ OncoImmunology ] - 2020.06.01
    40. Role of whole-body MRI for treatment response assessment in multiple myeloma: comparison between clinical response and imaging response. [ CANCER IMAGING ] - 2020.01.30
    41. Development and Validation of a Deep Learning System for Segmentation of Abdominal Muscle and Fat on Computed Tomography. [ KOREAN JOURNAL OF RADIOLOGY ] - 2020.01.01
    42. Impact of remnant stomach volume and anastomosis on nutrition and body composition in gastric cancer patients [ SURGICAL ONCOLOGY-OXFORD ] - 2019.12.01
    43. Progressive loss of muscle mass could be an adverse prognostic factor of 28-day mortality in septic shock patients [ SCIENTIFIC REPORTS ] - 2019.11.11
    44. Gadoxetate-enhanced dynamic contrast-enhanced MRI for evaluation of liver function and liver fibrosis in preclinical trials [ BMC MEDICAL IMAGING ] - 2019.11.01
    45. Impact of Body Composition Status on 90-Day Mortality in Cancer Patients with Septic Shock: Sex Differences in the Skeletal Muscle Index. [ Journal of clinical medicine ] - 2019.10.02
    46. Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects. [ PLoS One ] - 2019.09.01
    47. Magnetic Resonance Colonography Enables the Efficacy Assessment of Immune Checkpoint Inhibitors in an Orthotopic Colorectal Cancer Mouse Model [ TRANSLATIONAL ONCOLOGY ] - 2019.09.01
    48. Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems [ Cancers ] - 2019.09.01
    49. A Good Practice-Compliant Clinical Trial Imaging Management System for Multicenter Clinical Trials: Development and Validation Study. [ JMIR Medical Informatics ] - 2019.08.30
    50. Technical Performance of Two-Dimensional Shear Wave Elastography for Measuring Liver Stiffness: A Systematic Review and Meta-Analysis [ KOREAN JOURNAL OF RADIOLOGY ] - 2019.06.01
    51. Optimal Phase of Dynamic Computed Tomography for Reliable Size Measurement of Metastatic Neuroendocrine Tumors of the Liver: Comparison between Pre- and Post-Contrast Phases [ KOREAN JOURNAL OF RADIOLOGY ] - 2018.12.01
    52. Shear Wave Elastography as a Quantitative Biomarker of Clinically Significant Portal Hypertension: A Systematic Review and Meta-Analysis [ AMERICAN JOURNAL OF ROENTGENOLOGY ] - 2018.05.01
    53. Performing Gadoxetic Acid-Enhanced MRI After CT for Guiding Curative Treatment of Early-Stage Hepatocellular Carcinoma: A Cost-Effectiveness Analysis [ AMERICAN JOURNAL OF ROENTGENOLOGY ] - 2018.02.01
    54. Evaluation of drug mechanism and efficacy of a novel anti-angiogenic agent, TTAC-0001, using multi-modality bioimaging in a mouse breast cancer orthotopic model [ PLOS ONE ] - 2018.01.25
    55. A cost-effectiveness analysis of the diagnostic strategies for differentiating focal nodular hyperplasia from hepatocellular adenoma [ EUROPEAN RADIOLOGY ] - 2018.01.01
    56. Hypervascular Transformation of Hypovascular Hypointense Nodules in the Hepatobiliary Phase of Gadoxetic Acid?Enhanced MRI: A Systematic Review and Meta-Analysis [ AMERICAN JOURNAL OF ROENTGENOLOGY ] - 2017.10.01
    57. Correlations between renal function and the total kidney volume measured on imaging for autosomal dominant polycystic kidney disease: A systematic review and meta-analysis [ EUROPEAN JOURNAL OF RADIOLOGY ] - 2017.10.01
    58. Enhanced efficacy of radiofrequency ablation for hepatocellular carcinoma using a novel vascular disrupting agent, CKD-516 [ HEPATOLOGY INTERNATIONAL ] - 2017.09.01
    59. The Effects of Breathing Motion on DCE-MRI Images: Phantom Studies Simulating Respiratory Motion to Compare CAIPIRINHA-VIBE, Radial-VIBE, and Conventional VIBE [ KOREAN JOURNAL OF RADIOLOGY ] - 2017.03.01
    60. A META-ANALYSIS FOR THE DIAGNOSTIC PERFORMANCE OF TRANSIENT ELASTOGRAPHY FOR CLINICALLY SIGNIFICANT PORTAL HYPERTENSION [ ULTRASOUND IN MEDICINE AND BIOLOGY ] - 2017.01.01
    61. Feasibility of test-bolus DCE-MRI using CAIPIRINHA-VIBE for the evaluation of pancreatic malignancies [ EUROPEAN RADIOLOGY ] - 2016.11.01
    62. CT gastrography for volumetric measurement of remnant stomach after distal gastrectomy: a feasibility study [ ABDOMINAL RADIOLOGY ] - 2016.10.01
    63. Feasibility of free-breathing dynamic contrast-enhanced MRI of the abdomen: a comparison between CAIPIRINHA-VIBE, Radial-VIBE with KWIC reconstruction and conventional VIBE. [ BRITISH JOURNAL OF RADIOLOGY ] - 2016.10.01
    64. Perfusion MRI as the predictive/prognostic and pharmacodynamic biomarkers in recurrent malignant glioma treated with bevacizumab: a systematic review and a time-to-event meta-analysis. [ JOURNAL OF NEURO-ONCOLOGY ] - 2016.06.01
    65. Comparison of CAIPIRINHA-VIBE, Radial-VIBE, and conventional VIBE sequences for dynamic contrast-enhanced (DCE) MRI: A validation study using a DCE-MRI phantom. [ MAGNETIC RESONANCE IMAGING ] - 2016.06.01
    66. Diffusion-weighted Magnetic Resonance Enterography for Evaluating Bowel Inflammation in Crohn's Disease: A Systematic Review and Meta-analysis [ INFLAMMATORY BOWEL DISEASES ] - 2016.03.01
    67. Systematic Review and Meta-Analysis of Studies Evaluating Diagnostic Test Accuracy: A Practical Review for Clinical Researchers-Part I. General Guidance and Tips [ KOREAN JOURNAL OF RADIOLOGY ] - 2015.11.01
    68. Systematic Review and Meta-Analysis of Studies Evaluating Diagnostic Test Accuracy: A Practical Review for Clinical Researchers-Part II. Statistical Methods of Meta-Analysis [ KOREAN JOURNAL OF RADIOLOGY ] - 2015.11.01
    69. The diagnostic value of Gd-EOB-DTPA-MRI for the diagnosis of focal nodular hyperplasia: a systematic review and meta-analysis [ EUROPEAN RADIOLOGY ] - 2015.04.01
    70. Fluid Retention Associated with Imatinib Treatment in Patients with Gastrointestinal Stromal Tumor: Quantitative Radiologic Assessment and Implications for Management [ KOREAN JOURNAL OF RADIOLOGY ] - 2015.03.31
    71. Enhanced efficacy of CKD-516 in combination with doxorubicin: pre-clinical evaluation using a hepatocellular carcinoma xenograft model. [ ANTICANCER RESEARCH ] - 2014.04.01
    72. Imaging Features to Distinguish Malignant and Benign Branch-Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Meta-analysis. [ ANNALS OF SURGERY ] - 2014.01.01
    73. End-therapy positron emission tomography for treatment response assessment in follicular lymphoma: a systematic review and meta-analysis. [ CLINICAL CANCER RESEARCH ] - 2013.12.01
    74. Update in the management of gastroenteropancreatic neuroendocrine tumors with emphasis on the role of imaging. [ AMERICAN JOURNAL OF ROENTGENOLOGY ] - 2013.10.01
    75. Update on imaging of vulvar squamous cell carcinoma. [ AMERICAN JOURNAL OF ROENTGENOLOGY ] - 2013.07.01
    76. Ipilimumab-associated colitis: CT findings. [ AMERICAN JOURNAL OF ROENTGENOLOGY ] - 2013.05.01
    77. Cancer of unknown primary sites: what radiologists need to know and what oncologists want to know. [ AMERICAN JOURNAL OF ROENTGENOLOGY ] - 2013.03.01
    78. Ipilimumab associated hepatitis: imaging and clinicopathologic findings. [ INVESTIGATIONAL NEW DRUGS ] - 2013.02.01

    연구과제 수주실적

    1. K-BIO 해외임상시험 진출을 위한 국제기준 임상시험 융합 인포매틱스 및 규제기술 (Trial Informatics & RegTech) 시스템 개발 - 2024.03.01 ~ 2025.02.28
    2. K-BIO 해외임상시험 진출을 위한 국제기준 임상시험 융합 인포매틱스 및 규제기술 (Trial Informatics & RegTech) 시스템 개발 - 2023.03.01 ~ 2024.02.29
    3. 건강검진 CT에서 인공지능을 활용한 근감소증, 근지방증, 비만자동측정 프로세스 구축 및 표준결과보고서 개발 - 2022.08.01 ~ 2023.07.31
    4. [연구책임자: 이정현] CDISC 국제표준 준수 영상 품질관리 자동화 솔루션 개발 - 2022.06.01 ~ 2022.08.19
    5. K-BIO 해외임상시험 진출을 위한 국제기준 임상시험 융합 인포매틱스 및 규제기술 (Trial Informatics & RegTech) 시스템 개발 - 2022.03.01 ~ 2023.02.28
    6. 다양한 임상코호트 구성을 통한 학습_검증용 데이터셋 수집 및 임상적 검증을 통한 개발지원 - 2022.01.01 ~ 2022.12.31
    7. [연구책임자: 이정현] CDISC 국제표준 준수 영상 품질관리 자동화 솔루션 개발 - 2021.06.01 ~ 2022.05.31
    8. K-BIO 해외임상시험 진출을 위한 국제기준 임상시험 융합 인포매틱스 및 규제기술 (Trial Informatics & RegTech) 시스템 개발 - 2021.03.01 ~ 2022.02.28
    9. 급성 및 만성 위염 환자에서 CKD 495의 유효성과 안전성을 비교 평가하기 위한 무작위배정, 이중눈가림, 다기관, 제 3상 임상시험의 영상 품질관리 등 - 2020.11.25 ~ 2021.06.30
    10. 재발성 또는 불응성 비강형 결절외 NK T 세포 림프종 환자에서 IMC 001의 유효성과 안전성을 평가하기 위한 공개 라벨, 단일군, 글로벌 제 2상 시험의 영상 품질관리 등 - 2020.06.29 ~ 2025.07.31
    11. 급성 또는 만성 위염 환자에서 DWP14012의 유효성 및 안전성을 평가하기 위한 다기관, 이중눈가림, 무작위배정, 위약대조, 평행군, 3상, 치료적 확증 임상시험의 영상 품질관리 등 - 2020.04.27 ~ 2021.06.30
    12. A Multicenter, Open Label, Phase II Clinical Trial to Evaluate the Safety and Efficacyof TTAC 0001, a Fully Human Monoclonal Antibody in Patients with RecurrentGlioblastoma Progressed on Bevacizumab Including Therapy 임상시험의 영상 품질관리 및 독립적 영 - 2020.03.23 ~ 2023.03.31
    13. 중등증 이상의 급성 췌장염 환자 대상 SCM AGH의 유효성 및 안전성을 평가하기 위한 제 1 2a상 임상시험 - 2020.03.12 ~ 2020.12.31
    14. 항암신약개발에서 빅데이터와 영상인포매틱스를 활용한 국제기준에 맞는 전인적 통합 피료평가 시스템 개발 - 2020.03.01 ~ 2021.02.28
    15. 항암신약개발에서 빅데이터와 영상인포매틱스를 활용한 국제기준에 맞는 전인적 통합 피료평가 시스템 개발 - 2019.03.01 ~ 2020.02.29
    16. A phase 1b, open-label, safety and tolerability study of TTAC-0001 in Combination with Pembrolizumab - 2018.11.20 ~ 2019.12.31
    17. 미란성 위식도 역류질환 환자에서 DWP14012의 안전성 및 유효성을 평가하기 위한 다기관, 무작위배정, 이중눈가림, 활성대조, 3상, 치료적 탐색 임상시험의 영상 품질관리 등 - 2018.09.03 ~ 2019.12.31
    18. 다양한 임상코호트구성을 통한 학습/검증용 데이터셋 수집 및 임상적 검증을 통한 개발지원 - 2018.05.30 ~ 2018.12.31
    19. 상피세포 성장인자 수용체 돌연변이 양성(EGFRm+) 진행성 비소세포폐암(NSCLC) 환자를 대상으로 YH25448의 안전성, 내약성, 약동학 및 항암 작용을 평가하기 위한 제1상 - 2018.05.21 ~ 2019.12.31
    20. 진행성, 비절제성 HPV type 16 및/또는 18 양성 자궁경부암 환자에서 GX-188E 백신과 Pembrolizumab 병용치료의 다기관, 공개, 제1b-II상 임상시험의 영 - 2018.03.06 ~ 2021.06.30
    21. 항암신약개발에서 빅데이터와 영상인포매틱스를 활용한 국제기준에 맞는 전인적 통합 피료평가 시스템 개발 - 2018.03.01 ~ 2019.02.28
    22. 전이성 또는 국소 진행성 고형암 환자에서 IMC-001의 안전성, 약동학, 약력학 및 임상적 효능을 평가하기 위한 제1상, 공개라벨, 다중용량상승 시험(Protocol No.IMC - 2018.02.06 ~ 2019.12.31
    23. Luciferase 발현 Hep3B 간암세포주에서 RFA 수행시, RFA tip에 간암세포 생존 여부 확인 - 2018.01.08 ~ 2018.11.16
    24. 위암환자의 위 절제술 후 담석 형성의 예방에 대한 DW1319의 유효성 및 안전성을 평가하기 위한 다기관, 무작위배정, 이중눈가림, 위약대조 임상시험 영상 품질관리 등 - 2018.01.03 ~ 2019.12.31
    25. 항암신약개발에서 빅데이터와 영상인포매틱스를 활용한 국제기준에 맞는 전인적 통합 피료평가 시스템 개발 - 2017.03.01 ~ 2018.02.28
    26. 항암제 다기관 임상시험시 다중기능MRI를 이용하기 위한 국제적 기준에 맞는 정도관리 시스템 구축(3) - 2016.05.01 ~ 2017.04.30
    27. 항암제 다기관 임상시험시 다중기능MRI를 이용하기 위한 국제적 기준에 맞는 정도관리 시스템 구축(2) - 2015.05.01 ~ 2016.04.30
    28. 항암제 다기관 임상시험시 다중기능MRI를 이용하기 위한 국제적 기준에 맞는 정도관리 시스템 구축(1) - 2014.05.01 ~ 2015.04.30

    특허/기술이전실적

    1. 내부용기에 표준물질을 담은 의료 영상용 표준 팬텀 - 2021.12.10
    2. 뇌질환 임상시험용 표준 팬텀 - 2021.09.24
    3. 인공지능을 이용한 방사선 영상에서의 요추 영역 분석 방법, 이를 수행하기 위한 기록매체 및 장치 - 2020.07.27
    4. 근감소증 분석지원을 위한 인공 신경망 기반의 인체 형태 분석법을 채용하는 영상 처리 장치 및 이를 이용한 영상 처리 방법 - 2019.10.02
    5. 호흡운동에 따른 동적영상 정합용 복부 팬텀장치 - 2016.03.25

    국내외 경력

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